Effects of morphine and hashish (Cannabis sativa) on activities of human red blood cell carbonic anhydrase isoenzymes

Demir Y., Alayli A., Demir N.

Pharmaceutical Biology, cilt.42, sa.6, ss.434-439, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/13880200490886094
  • Dergi Adı: Pharmaceutical Biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.434-439
  • Atatürk Üniversitesi Adresli: Evet

Özet

Carbonic anhydrase (CA) exists in all living organisms and converts CO2 (waste product) to H2CO3. Two different forms of CA are present in human erythrocytes. These forms are known as CA-I and CA-II. Whereas CA-I has a low activity, CA-II is highly active. In the current study, CA-I and CA-II were purified by affinity chromatography from human blood. Then the effects of hashish (Cannabis sativa L.) and morphine on the CA-I and CA-II activities were measured by following esterase activity, and the results are presented.