The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea

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KERGET B., Kerget F., YÜCE KAHRAMAN Ç., Aksakal A., ARAZ Ö.

UPSALA JOURNAL OF MEDICAL SCIENCES, cilt.126, sa.1, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 126 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.48101/ujms.v126.7603
  • Dergi Adı: UPSALA JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: Obstructive sleep apnea, polymorphism, vaspin, NLRP3, Elisa, OXIDATIVE STRESS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS). ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome. In this study, we aimed to investigate the effect of NLRP3 rs10159239 (rs9239) and vaspin rs2236242 (rs6242) single nucleotide polymorphisms (SNPs) on OSA development.