r.In patients with ichthyosis, most tinea lesions are not well defined, so careful clinical examination is imperative to detect these lesions. Round patches with erythematous scaly circinate margins are commonly seen due to the combination of keratin degradation and host inflammatory response. It may be common enough to cause erythroderma. This hyperkeratotic epidermis of ichthyotic skin provides a nutritious microbiological environment for dermatophytes. Disruption of cellular immunity, Th1/Th2 imbalance is the characteristic feature of the host organism that makes it susceptible to fungal infections. Th2 dominance and atopic predisposition are particularly prominent in ichthyosis strains. Macrophage dysfunction may also play an important role in the development of the disease.. Effective treatment should be initiated as soon as possible to avoid chronic dermatophytosis and superinfections.. Therefore, in any patient with ichthyosis who develops pruritus or unexplained exacerbation of erythroderma, fungal infection should be ruled out first