Efficacy of glutathione mesotherapy in burns: an experimental study

Buz A., Gorgulu T., Olgun A., Kargi E.

European Journal of Trauma and Emergency Surgery, cilt.42, sa.6, ss.775-783, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00068-015-0607-8
  • Dergi Adı: European Journal of Trauma and Emergency Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.775-783
  • Anahtar Kelimeler: Burn, Mesotherapy, Glutathione, Taurine, L-Carnitine, XANTHINE-OXIDASE, INJURY, MANAGEMENT, WOUNDS, MODEL, RAT, EXPRESSION, INHIBITORS, TISSUE, TURKEY
  • Atatürk Üniversitesi Adresli: Hayır

Özet

Thermal burns are the leading cause of trauma worldwide. Currently, no consensus on optimal treatment of deep partial-thickness (second-degree) burns has emerged, as reflected by the wide variability in available wound-care materials. The relative efficacies of products used for treatment of partial-thickness thermal burns remain unclear. Mesotherapy features intradermal administration of various agents, depending on burn location. In the present experimental study, we explored the efficacy of mesotherapy used to treat partial-thickness thermal burns in 50 male Wistar rats divided into five groups of equal number. No procedure was performed after infliction of thermal burns in control group (Group 1). Mesotherapy was applied with physiological saline in sham group (Group 2), glutathione, taurine, and l-carnitine were separately applied in Group 3, Group 4, and Group 5, respectively.