Gastroprotective and antioxidant effects of amiodarone on lndomethacin-induced gastric ulcers in rats


Dengiz G. O., Odabasoglu F., Halici Z., Suleyman H., Cadirci E., Bayir Y.

ARCHIVES OF PHARMACAL RESEARCH, cilt.30, sa.11, ss.1426-1434, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/bf02977367
  • Dergi Adı: ARCHIVES OF PHARMACAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1426-1434
  • Anahtar Kelimeler: amiodarone, indomethacin, gastroprotective effect, myeloperoxiclase, antioxidant enzymes, LIPID-PEROXIDATION, MUCOSAL DAMAGE, FREE-RADICALS, INDOMETHACIN, PATHOGENESIS, INHIBITION, INJURY, OXYGEN, NEUTROPHILS, STRESS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Reactive oxygen species (ROS) have been implicated in the etiology-of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) arniodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) arniodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of arniodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.