Overexpression of c-Met in cervical intraepithelial neoplasia

Comunoglu C., Boynukahn K., Ugur M. G., Al R. A., Kuzey G. M., Baykal C.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, cilt.33, sa.6, ss.625-628, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2012
  • Dergi Adı: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.625-628
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose of investigation: The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN). Materials and Methods: Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as Normal cervical mucosas from five patients were studied with c-Met as control cases. Results: Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases. Conclusion: These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.