Levosimendan ameliorates cisplatin-induced ototoxicity: Rat model

GÖZELER M. S., AKDEMİR F. N. E., YILDIRIM S., ŞAHİN A., Eser G., AŞKIN S.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.122, ss.70-75, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 122
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.ijporl.2019.04.004
  • Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.70-75
  • Anahtar Kelimeler: Cisplatin-induced ototoxicity, Levosimendan, DPOAE, 8-Hydroxy-2 ' deoxyguanosine, Caspase-3, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objectives: Cisplatin is employed for chemotherapeutic purposes in several types of adult and pediatric cancer. However, side-effects including nephrotoxicity, ototoxicity, gastrointestinal effects and neuropathy restrict the use of the drug due to their adverse impacts on quality of life. This study aimed to determine whether levosimendan exhibits a protective effect against cisplatin-related ototoxicity in a rat model by means of functional, biochemical and histochemical analysis.