The effects of vitamin E and selenium on blood flow to experimental skin burns in rats using the Xe-133 clearance technique

Varoglu E., Seven B., Gümüştekin K., Aktaş O., Şahin A., Dane S.

CENTRAL EUROPEAN JOURNAL OF MEDICINE, cilt.5, ss.219-223, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2478/s11536-009-0081-y
  • Dergi Adı: CENTRAL EUROPEAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-223
  • Anahtar Kelimeler: Vitamin E, Selenium, Wound healing, Blood flow, Xenon-133, NICOTINE, WASHOUT, WOUNDS, TISSUE, ZINC
  • Atatürk Üniversitesi Adresli: Evet

Özet

The aim of the present experimental study was to determine and to compare the effects of vitamin E and of selenium on the blood flow to a wound region in rats, using the xenon-133 (Xe-133) clearance technique. Burn wounds were made on the right thighs of rats followed by oral administration of vitamin E or selenium for a period of 10 days. The effect of vitamin E and of selenium individually on blood flow in the wound region was assessed before and after oral administration using the Xe-133 clearance technique. Both vitamin E and selenium significantly increased the blood flow in the wound region (P < 0.05). Our results in rats suggest that both vitamin E and selenium have beneficial effects on the skin wound healing process by increasing the skin blood flow.