Akademik Veri Yönetim Sistemi
II. International VET istanbul Group Congress, Sankt-Peterburg, Rusya, 7 - 09 Nisan 2015, ss.320
ABSTRACT. Paracetamol (Acelaminophen) is a non-prescription drug comrnonly
used fer antipyresis and analgesia. it contains a phenol ring, as does oestradiol, and an
acyl group as does progesterone. The aim of this study was investigation of the effects of
paracetamol on reproductiveand biochemicalparametersin male rats.
Material and Method: in !he study. 12 male Sprague Dawley rats aged eight weeks old
and weighted 250-300 gr, were used in this study. The animals were obtained from Atatürk
University Experimental Research Centre and housed in standard laboratory conditions.
Commercial pellet chow and fresh drinking water were avaitable ad /ibitum. Rats were
divided into two groups.ı. group (n= 6) referred as control group andphysiological saline 1
vıa oral gavage tothe animalsll.group (n=6) referred as Paracetamol (P) was injectedi
2mg/kg per os (p.o.) to animals. The treatment was performed for consecutive 7 days.i
The animals were tranquilized and sacrificedon 8"'day of study. Cauda epididymal semen,
samples and testes tissues were collected. Routine semen examinations were perforrned;
and oxidative stress levels oftesticular tissues were assayed. Reproductive organ weights\
[total testes weight (TTW} and total cauda epididymides weights (TCEW) }were recordedi'
Results: Our results indlcated that velocity of sperm ceils in P group was significanUyl
ıower when compared to control group. There were no differences in terms of dead spermj
rate, sperm density, total abnormality, ITıN and TCEW among ali groups. Maiondialdehyde:
{MDA) level of P group was significantly higher compared ta control groups. Furthermoıel
catalase (Cat), glutathione peroxidase (GPx) and glutathione (GSH) levels in P group !
were lower compared to control group. :'
Conclusion: it was determine to effect of paracetamol on oxidanVantioxidant status iı
male rats. ··
Key words:Paracetamol, reproduction, rat.