A new approach for the synthesis of 2-substituted indole derivatives via Michael type adducts

Çavdar H., Saracoglu N.

TETRAHEDRON, cilt.61, sa.9, ss.2401-2405, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 9
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tet.2005.01.017
  • Dergi Adı: TETRAHEDRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2401-2405
  • Anahtar Kelimeler: indole, natural product, Michael reaction, electrophilic substitution, bismuth nitrate, alpha,beta-unsaturated compound, HAPALINDOLES, ALKALOIDS, SERIES
  • Atatürk Üniversitesi Adresli: Evet

Özet

4,7-Dihydroindole undergoes regioselective alkylation at the 2-position of the indole nucleus through conjugate addition with alpha,beta-unsaturated carbonyl compounds. The oxidation of the Michael adducts affords the corresponding 2-substituted indole derivatives which were characterized by spectroscopic methods. (C) 2005 Elsevier Ltd. All rights reserved.