Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity

POLAT B., Suleyman H., Sener E., Akcay F.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.20, sa.2, ss.221-229, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/1074248414552901
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.221-229
  • Anahtar Kelimeler: cardiotoxicity, doxorubicin, thiamine, thiamine pyrophosphate, thiamine pyrophosphokinase, CONGESTIVE-HEART-FAILURE, OXIDATIVE DNA-DAMAGE, TERM FUROSEMIDE THERAPY, ELECTROCHEMICAL DETECTION, CRITICALLY-ILL, SUPPLEMENTATION, DEFICIENCY, TISSUE, RAT, 8-HYDROXYGUANINE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.