Prognostic Value of Baseline Serum Lactate Dehydrogenase Level in Patients With Hairy Cell Leukemia

Maral S., Albayrak M., Dagdas S., Yildiz A., Yildirim R., Oz M., ...Daha Fazla

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.20, sa.9, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.clml.2020.04.005
  • Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Hairy cell leukemia (HCL) is rare and indolent lymphoproliferative disease that progresses with relapse and remission periods. We investigated the initial clinical characteristics and risk factors affecting the outcome of patients with HCL. Retrospective data of 65 HCL patients were evaluated according to patient characteristics, initial hematologic and biochemical parameters, response rates, progression-free survival (PFS), and overall survival. Patients with higher lactate dehydrogenase (LDH) levels experienced relapse and/or progression more frequently, and initial elevated LDH level was associated with shorter PFS.