Akademik Veri Yönetim Sistemi
Journal of veterinary science, cilt.25, sa.1, 2024 (SCI-Expanded)
Background: Canine parvoviral enteritis (CPE) is a fatal disease worldwide. The treatment
of CPE is based mainly on supportive and symptomatic treatment. Antiviral addition to the
treatment may result in a higher survival.
Objectives: This study evaluated the effects of antiviral treatments with a standardized
treatment (ST) on the clinical and inflammatory response of dogs with naturally occurring CPE.
Methods: Twenty-eight dogs with CPE caused by canine parvovirus type 2 were divided
randomly into treatment groups. The ST group received fluid, antibiotic, antiemetic,
and deworming treatments. The antiviral treatment groups received the same ST with an
additional antiviral drug, recombinant feline interferon omega (rFeIFN-ω), oseltamivir
(OSEL) or famciclovir (FAM).
Results: Compared to the healthy control, the tumor necrosis factor-α, interleukin-1β,
interferon (IFN)-α, IFN-γ, haptoglobin, and C-reactive protein values were high (p < 0.05)
on day zero. At presentation, mild lymphopenia, neutropenia, and a high neutrophil to
lymphocyte (LYM) ratio (NLR) were also observed. Adding rFeIFN-ω to the ST produced the
best improvement in the clinical score with a decreased NLR, while leucocytes remained low
and inflammatory markers stayed high on day three. The survival rates of the groups were
85.7% in ST+IFN, 71.4% in ST+OSEL, 71.4% in ST+FAM, and 57.1% in ST groups on day seven.
Conclusions: Antiviral drugs may be valuable in treating CPE to improve the clinical signs
and survival. In addition, the decrease in NLR in favor of LYM may be an indicator of the early
prognosis before the improvement of leukocytes, cytokines, and acute phase proteins in CPE.
Keywords: Acute-phase proteins; canine parvovirus; cytokines; leukocyte