C6-H Bond Functionalization of Indoles: A New Gate

Taşkesenligil Y., Saraçoğlu N.

SYNTHESIS-STUTTGART, cilt.55, sa.21, ss.3417-3433, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 21
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1055/a-2050-4897
  • Dergi Adı: SYNTHESIS-STUTTGART
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
  • Sayfa Sayıları: ss.3417-3433
  • Anahtar Kelimeler: indole, C-H bond activation, directing group (DG), transition metal (TM), acid catalyst, hydrogen bond, electrophilic aromatic substitution (EAS), C-H FUNCTIONALIZATION, O-QUINONE METHIDES, ARYLATION, ALKYLATION, 3-INDOLYLMETHANOLS, ACTIVATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Indoles are valuable precursors in medicinal, bioorganic, and material chemistry and particularly serve as a platform for diversity. However, the scope of the C6-functionalization of indoles was limited until recently. In this short review, we summarize developments in the C6-functionalization reactions of indoles involving transition-metal-cat-alyzed functionalization and Brunsted and Lewis acid catalyzed process -es. The regioselectivity is controlled by remote-C-H activation and hy-drogen bond formation. 1 Introduction 2 Transition-Metal-Catalyzed Functionalization 3 Acid-Catalyzed Processes 4 Conclusion