An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper Istraživanje tiol-disulfidne homeostaze i razine albumina modificiranog ishemijom radi procjene oksidacijskog stresa u pasa sa štenećakom

DEĞİRMENÇAY Ş., Çamkerten G., Çamkerten İ., Sinan Aktaş M.

Veterinarski Arhiv, cilt.91, sa.1, ss.39-49, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.24099/vet.arhiv.0867
  • Dergi Adı: Veterinarski Arhiv
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.39-49
  • Anahtar Kelimeler: canine distemper, oxidative stress, thiol/disulfide homeostasis, ischemia-modified albumin, VIRUS-INFECTION, PATHOGENESIS, DIAGNOSIS, INDEXES, PLASMA, MARKER
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2021, University of Zagreb, Facultty of Veterinary Medicine. All rights reserved.This study aimed to investigate the diagnostic value of thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels in evaluating oxidative stress in dogs with canine distemper. The study materials consisted of 24 cross-breed dogs: 18 dogs with canine distemper (CD group) and 6 healthy dogs as the control. Blood samples for analysis of antioxidant-oxidant parameters were taken from both groups. In addition to TDH parameters (native thiol [NT], total thiol [TT], and disulfide [Ds] levels and Ds/NT, Ds/TT, and NT/TT ratios), IMA and albumin (ALB) levels were also determined in the blood serum of the groups. The IMA levels of the CD group were significantly higher than the control group (P<0.05). Antioxidant parameters (NT, TT) and oxidant parameters (Ds, Ds/NT, and Ds/TT) both exhibited a significant positive correlation among themselves (P<0.01). The areas under the ROC curve of IMA, Ds/ NT, and Ds/TT were 0.78, 0.62, and 0.62 respectively. The high levels of IMA, Ds, Ds/NT, and Ds/TT and low levels of NT, TT, NT/TT and ALB in dogs with canine distemper can be used to assess the oxidative stress caused by the disease. Overall, the diagnostic performances of IMA, Ds/NT, and Ds/TT for detection of increased oxidative stress were similar, but IMA was superior.