Oxidative stress activity of fingolimod in multiple sclerosis.

Yevgi R., Demir R.

Clinical neurology and neurosurgery, cilt.202, ss.106500, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 202
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.clineuro.2021.106500
  • Dergi Adı: Clinical neurology and neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.106500
  • Anahtar Kelimeler: Multiple sclerosis, Fingolimod, Oxidative stress, Antioxidant, Expanded Disability Status Scale (EDSS)
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Multiple sclerosis (MS) is a demyelinating chronic inflammatory disease of the central nervous system (CNS). Recent studies have shown that oxidative stress plays an important role in MS pathogenesis. This study aimed to investigate the relationship between total oxidative stress (TOS) and total antioxidant capacity (TAC), which were reported to be effective in the pathogenesis of MS, and therapeutic efficacy of fingolimod used in the treatment of MS.