Fibroblast Growth Factor-23 and Carotid Artery Intima Media Thickness in Chronic Kidney Disease

Yilmaz G., Ustundag S., Temizoz O., Sut N., Demir M., Ermis V., ...Daha Fazla

CLINICAL LABORATORY, cilt.61, sa.8, ss.1061-1070, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.7754/clin.lab.2015.141236
  • Dergi Adı: CLINICAL LABORATORY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1061-1070
  • Anahtar Kelimeler: atherosclerosis, fibroblast growth factor 23, intima media thickness, LEFT-VENTRICULAR HYPERTROPHY, CARDIOVASCULAR-DISEASE, HEMODIALYSIS-PATIENTS, DIALYSIS PATIENTS, MORTALITY RISK, FGF23, CALCIFICATION, PROGRESSION, PHOSPHORUS, CALCIUM
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: The cause of early-accelerated atherosclerosis development observed in Chronic Kidney Disease (CKD) is not fully understood. The determination of the relationship between the levels of fibroblast growth factor 23 (FGF-23) and the development of endothelial dysfunction, left ventricular hypertrophy, and myocardial infarction lends support to the possibility that FGF-23 plays a role in the development of atherosclerosis in CKD. Only a few studies, however, have been conducted that analyze the relationship between FGF-23 levels in the progression of CKD and the development of atherosclerosis, and these studies have generally been limited to those patients receiving dialysis therapy due to end stage renal disease (ESRD).