A short synthesis of 4-amino-3-hydroxybutyric acid (GABOB) via allyl cyanide


Mete E. , Maras A. , Secen H.

RUSSIAN CHEMICAL BULLETIN, vol.52, no.8, pp.1879-1881, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 8
  • Publication Date: 2003
  • Doi Number: 10.1023/a:1026045829876
  • Title of Journal : RUSSIAN CHEMICAL BULLETIN
  • Page Numbers: pp.1879-1881

Abstract

4-Amino-3-hydroxybutyric acid was synthesized from allyl cyanide in four steps in an overall yield of 38%. Ultrasonically promoted epoxidation of allyl cyanide with m-chloroperoxy-benzoic acid giving oxiranylacetonitrile was used as a key step.