Investigation of the Anticancer Mechanism of Isoorientin Isolated from Eremurus Spectabilis Leaves via Cell Cycle Pathways in HT-29 Human Colorectal Adenocarcinoma Cells

Gundogdu G., Dodurga Y., Elmas L., Tasci Ş., Karaoglan E. S.

EURASIAN JOURNAL OF MEDICINE, cilt.50, sa.3, ss.168-172, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/eurasianjmed.2018.17403
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.168-172
  • Anahtar Kelimeler: Isoorientin, colorectal cancer, cell cycle pathway, CANCER-PATIENTS, G(1) ARREST, APOPTOSIS, SURVIVAL, TARGET, CHECKPOINT, EXPRESSION, THERAPY, ERCC1, CDK4
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Isoorientin (ISO) is a flavonoid compound extracted from plant species. The goal of this study was to determine the potential antiproliferative effects of ISO in HT-29 human colorectal adenocarcinoma cell line in vitro, specifically on cell viability, apoptosis, and cell cycle pathways.