Effect of intermittent hypoxia on the cardiac HIF-1/VEGF pathway in experimental type 1 diabetes mellitus

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Guzel D., Dursun A. D., Ficicilar H., Tekin D., TANYELİ A., Akat F., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, sa.2, ss.76-83, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/akd.2015.5925
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.76-83
  • Anahtar Kelimeler: angiogenesis, diabetic cardiomyopathy, intermittent hypoxia, HIF-1, VEGF, ENDOTHELIAL GROWTH-FACTOR, INDUCIBLE FACTOR-1-ALPHA, MYOCARDIAL-ISCHEMIA, FACTOR EXPRESSION, CARDIOMYOPATHY, HEART, ANGIOGENESIS, RAT, ECHOCARDIOGRAPHY, OVEREXPRESSION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: High altitude and hypoxic preconditioning have cardioprotective effects by increasing coronary vascularity, reducing post-ischemic injury, and improving cardiac function. Our purpose was to examine if intermittent hypoxia treatment has any restoring effects related to the possible role of the HIF-1/VEGF pathway on diabetic cardiomyopathy.