Akademik Veri Yönetim Sistemi
Colloids and Surfaces A: Physicochemical and Engineering Aspects, cilt.722, 2025 (SCI-Expanded)
This study hypothesizes that integrating β-cyclodextrin into a metal[sbnd]organic framework (β-CD-MOF) structure can yield a biocompatible, high-efficiency carrier with enhanced physicochemical properties suitable for pH-responsive drug delivery. β-CD-MOF was synthesized via an ultrasound-assisted route and optimized through Box–Behnken response surface methodology to maximize yield and structural performance. The solvent volume and reaction temperature were identified as significant variables, with an optimal yield of 82.39 % achieved at a molar ratio of 8:1, 20 mL of solvent, and 60 °C. Characterization via SEM, FTIR, XRD, and N₂ adsorption–desorption isotherms confirmed the successful formation of a lamellar structure with a high surface area (332.13 m²/g), which slightly decreased to 247.07 m²/g after the encapsulation of 2-hydroxybenzothiazole (HBOT). In vitro release studies revealed pH-dependent kinetics: first-order diffusion prevailed at pH 2 (R² = 0.977), whereas non-Fick transport, modeled by the Ritger–Peppas equation (R² = 0.97, n = 0.70), dominated at pH 7 owing to combined swelling and diffusion mechanisms. The HBOT/β-CD-MOF composite demonstrated superior antibacterial performance against Shigella flexneri and Escherichia coli, achieving an inhibition zone of 21.54 ± 0.43 mm, outperforming free HBOT by leveraging sustained drug release. Cytotoxicity assessments via CCK-8 assays confirmed high biocompatibility, with over 103 % cell viability at 800 μg/mL. Overall, this work presents a scalable, environmentally friendly approach to developing multifunctional MOF-based carriers with responsive release profiles, offering promising potential for safer, longer-acting, and more targeted antibacterial therapies.