Estimated glomerular filtration rate is associated with both arterial stiffness and N-terminal pro-brain natriuretic peptide in newly diagnosed hypertensive patients


Gur M., Ucar H., Kuloglu O., Kivrak A., Seker T., Turkoglu C., ...More

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.36, no.6, pp.374-379, 2014 (SCI-Expanded) identifier identifier identifier

Abstract

Even a slight decrease in the glomerular filtration rate (GFR) is an independent risk factor for cardiovascular disease. Arterial stiffness, left ventricular hypertrophy and N-terminal pro-brain natriuretic peptide (NT-proBNP) are independent risk factors for cardiovascular disease, which are particularly common in end-stage renal disease. We aimed to evaluate the association between GFR with arterial stiffness, left ventricle mass (LVM) and NT-proBNP in hypertensive subjects with normal to mildly impaired renal function. The study population consisted of 285 newly diagnosed hypertensive patients (mean age; 49.9 +/- 11.8 years). GFR was estimated (eGFR) by the Modification of Diet in Renal Disease formula. Pulse wave velocity (PWV) and augmentation index (AIx), which reflects arterial stiffness, were calculated using the single-point method via the Mobil-O-Graph (R) ARCsolver algorithm. LVM was obtained by echocardiography. Plasma NT-proBNP was measured by electrochemiluminescence. The patients were divided into two groups according to the median eGFR value (eGFR(low) group < 101 ml/min/1.73 m(2) and eGFR(high) group >= 101 ml/min/1.73 m(2)). LVM and NT-proBNP values were higher in eGFR(low) group compared with eGFR(high) group (p50.05). Pulse wave velocity and augmentation index values were higher in eGFR(low) group compared with eGFR(high) group (p50.05, for all). Multiple linear regression analysis showed that eGFR was independently associated with PWV (beta = -0.422, p < 0.001) and NT-proBNP (beta = -0.404, p < 0.001). Present study showed that eGFR was independently associated with PWV and NT-proBNP values. Importantly, these findings may explain, in part, the increase in cardiovascular risk in with slightly impaired renal function.