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By 2030, the bio-based economy is expected to have grown significantly in Europe. One of the pillars of this bioeconomy is the concept of BIOREFINERY, the sustainable processing of several kinds of waste and biomass into a spectrum of marketable products and energy. While in the past many research efforts have been conducted towards understanding, modelling and designing conversion processes that can sustain a true circular economy, this KNOWLEDGE IS QUITE FRAGMENTED and UNEVENLY DISTRIBUTED across Europe. Several countries lack proper policies and public engagement to endeavour the challenges ahead. HARMONIZATION must start on ROBUST KNOWLEDGE, and the ability to cover the WHOLE VALUE-CHAIN, from source materials up to the marketable products… and that is WIRE’s mission.