Akademik Veri Yönetim Sistemi
Gürol A., Bakan B. (Yürütücü), Tanrıverdi Eçik E., Şişman T.
Diğer Ülkelerdeki Özel Organizasyonlar Tarafından Desteklenmiş Proje, 2025 - 2025
| The primary objective of this study is to investigate the effects of particle size on the structural and chemical characteristics of cisplatin-loaded Fe₃O₄ nanoparticles using synchrotron-based techniques. Specifically, the project aims to synthesized Fe₃O₄ nanoparticles in different size ranges (18-28nm and 50-100 nm) with cisplatin through surface functionalization in our laboratory. . In scope of proposal is to 1. determine the oxidation states and local chemical environments of iron (Fe) and platinum (Pt) atoms in the nanoparticle-drug formulation using X-ray Absorption Spectroscopy (XAS), including: Fe K-edge (to assess Fe²⁺/Fe³⁺ ratio) and Pt L₃-edge (to assess coordination and oxidation state of cisplatin after loading), 2. compare drug loading efficiency and bonding behavior as a function of particle size and surface properties. 3. correlate structural integrity and chemical composition with potential performance in drug delivery, especially regarding size-dependent cellular uptake and release behavior. 4. provide insights into the design of more effective magnetic nanoparticle-based drug carriers, contributing to the development of next-generation nanotheranostics with improved efficacy and reduced side effects. |