Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats

Caglayan C. , Kandemir F. M. , Yıldırım S., Küçükler S. , Eser G.

Journal of Trace Elements in Medicine and Biology, vol.54, pp.69-78, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jtemb.2019.04.007
  • Title of Journal : Journal of Trace Elements in Medicine and Biology
  • Page Numbers: pp.69-78


Objective: Mercury is a dangerous industrial and environmental pollutant which induces severe damage in diverse organs in animal and humans. The aim of this study was to investigate the protective effect of rutin (50 and 100 mg/kg body weight) against mercuric chloride (HgCl2) (1.23 mg/kg b.w.) toxicity in rats.