Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats

Caglayan C., Kandemir F. M., Yıldırım S., Küçükler S., Eser G.

Journal of Trace Elements in Medicine and Biology, cilt.54, ss.69-78, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jtemb.2019.04.007
  • Dergi Adı: Journal of Trace Elements in Medicine and Biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-78
  • Anahtar Kelimeler: Apoptosis, Inflammation, Mercuric chloride, Nephrotoxicity, Oxidative stress, Rutin, NF-KAPPA-B, ANTIOXIDANT ACTIVITY, DIETARY LUTEOLIN, SODIUM SELENITE, EXPRESSION, TOXICITY, EXTRACT, DAMAGE, ACTIVATION, ZINGERONE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Mercury is a dangerous industrial and environmental pollutant which induces severe damage in diverse organs in animal and humans. The aim of this study was to investigate the protective effect of rutin (50 and 100 mg/kg body weight) against mercuric chloride (HgCl2) (1.23 mg/kg b.w.) toxicity in rats.