Development and in vitro Characterization of Gastroretentive Formulations as Calcium Pectinate Hydrogel Pellets of Pregabalin by Ionotropic Gelation Method


Ozakar R. S.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, cilt.56, sa.1, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5530/ijper.56.1s.38
  • Dergi Adı: INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: Gastroretentive drug delivery, Pregabalin, Pectin, HPLC, FT-IR, BET, XRD, DRUG-DELIVERY SYSTEM, GEL BEADS, RELEASE, TABLETS, POLYSACCHARIDES, CARRIER, DESIGN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Introduction: Pregabalin (PG) is primarily prescribed for epilepsy, painful diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia. Also, it is used in clinical practice to treat general anxiety disorder due to its anxiolytic properties. Pectin is a water-soluble ionic polysaccharide. As a result of the interaction of pectin with calcium ions, a hydrophilically coated insoluble carrier system is formed by complexing between surfaces, which provides a sustained release. In this direction, floating hydrogel pellets containing PG were developed and characterized in our study. This study aimed to make a sustained release of PG, reach the optimum level in characterization, and bring a new approach to widely used oral drug therapy. Materials and Methods: PG was a gift from Ilko Pharmaceuticals (Turkey) and pectin was purchased from CPKelco (USA). The ionotropic gelation technique was used to prepare pellets. To characterize the pellets, flotation/swelling degrees, yield, drug loading capacity/encapsulation efficiency, particle size/distribution, in-vitro release/kinetics, and morphological studies have been done. Also, the structural features of pellets have determined via the Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), and X-ray diffraction (XRD) studies. Results: The formulations have been successfully developed without using any coating agent to prolong drug release for 24 h with an encapsulation efficiency of -82%. Optimum results were obtained in characterization studies. As a result of BET analysis, it has been proven that the structure is porous and there is no change in the chemical and crystal structure of PG by FT-IR and XRD studies. Conclusion: We anticipate that the formulation we developed will provide an alternative to the sustained-release PG preparations in the current pharmaceutical market.