The effects Metformin/Irinotecan-loaded PLGA nanoparticles on glutamate re-uptake time and alteration EAAT1 gene expression level in vitro

TAGHIZADEHGHALEHJOUGHI, ALI; HACIMÜFTÜOĞLU, Ahmet; ÇETİN, Meltem; Kaplan, Afife; Bütüner, Selcuk; Taspinar, Numan; Mohammadzadeh, Maryam

doi:10.22038/nmj.2019.06.005

The effects Metformin/Irinotecan-loaded PLGA nanoparticles on glutamate re-uptake time and alteration EAAT1 gene expression level in vitro

TAGHIZADEHGHALEHJOUGHI A., HACIMÜFTÜOĞLU A., ÇETİN M., Kaplan A. B. U., Bütüner S., Taspinar N., ...Daha Fazla

NANOMEDICINE JOURNAL, cilt.6, sa.1, ss.35-42, 2019 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 6 Sayı: 1
Basım Tarihi: 2019
Doi Numarası: 10.22038/nmj.2019.06.005
Dergi Adı: NANOMEDICINE JOURNAL
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
Sayfa Sayıları: ss.35-42
Anahtar Kelimeler: EAAT1, Irinotecan, Metformin, PLGA, Voltammetry, INDUCED NEUROTOXICITY, BREAST-CANCER, IRINOTECAN, METFORMIN, CYTOTOXICITY, GLIOBLASTOMA, GROWTH, CPT-11
Atatürk Üniversitesi Adresli: Evet

Özet

Objective(s): The present study was designed to evaluate of Metformin/Irinotecan-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) effects on glutamate re-uptake time and receptor expression status in both glioblastoma multiforme (GBM) and cortex neuron cultures. The study was performed on glioblastoma cell line and primer cortex neuron.