Preparation, Characterization of Chitosan-Coated/Uncoated Boron Nanoparticles and In-Vitro Evaluation of Their Antimicrobial Effects

Ozakar R., BİNGÖL M. S., ADIGÜZEL M. C., ÖZAKAR E.

POLYMER-KOREA, cilt.46, sa.6, ss.709-721, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.7317/pk.2022.46.6.709
  • Dergi Adı: POLYMER-KOREA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Sayfa Sayıları: ss.709-721
  • Anahtar Kelimeler: antibacterial activity, boron nitride, chitosan, nanoparticles, zeta potential, DELIVERY-SYSTEMS, NITRIDE NANOTUBES, CELLULAR UPTAKE, ANTIBACTERIAL, DRUG, NANOPRECIPITATION, BIOCOMPATIBILITY, NANOFIBERS, TOXICITY, SURFACES
  • Atatürk Üniversitesi Adresli: Evet

Özet

Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of mul-tidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates sci-entists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible properties, including cost-effectiveness. The aim of this study was to evaluate the antibacterial effect of boron nitride (BN) and chi-tosan coated BN-Nps using different surfactants. In this regard, the potential antibacterial activity of prepared chitosan-coated and non-coated BN-Nps have been investigated against nine reference bacteria strains. BN-Nps and chitosan-coated BN-Nps were successfully developed and characterized. Nps determined that showed high zeta potential values (between-20.1 mV and +59.2 mV). Antimicrobial resistance results indicated that formulations of BN-Nps with negative zeta potential were found to be effective compared to chitosan-coated BN-Nps with high positive zeta potential. These findings emphasize the future availability of BN-Nps formulation providing antibacterial activity.