Copy For Citation
UĞUR KAPLAN A. B., ÖZTÜRK N., ÇETİN M., VURAL İ., ÖZNÜLÜER ÖZER T.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.19, no.1, pp.84-92, 2022 (ESCI)
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Publication Type:
Article / Article
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Volume:
19
Issue:
1
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Publication Date:
2022
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Doi Number:
10.4274/tjps.galenos.2021.81905
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Journal Name:
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
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Journal Indexes:
Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
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Page Numbers:
pp.84-92
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Keywords:
Cytotoxicity, daidzein, FTIR analysis, nanosuspension, media milling, PLGA NANOPARTICLES, DOSAGE FORMS, NANOEMULSIONS, ENHANCEMENT
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Ataturk University Affiliated:
Yes
Abstract
Objectives: Daidzein (DZ), a water-insoluble isoflavone, has many beneficial effects (anti-inflammatory, antioxidant, and anticancer effects, etc.) on human health. DZ has a very low oral bioavailability related to its physicochemical properties (low solubility, intense metabolism of DZ in the intestine and liver). This study aimed to prepare and in vitro characterize the nanosuspension formulations of DZ to improve the poor solubility and efficacy of DZ.