Solid lipid nanoparticles loaded with lipoyl-memantine codrug: Preparation and characterization


LASERRA S., BASIT A., SOZIO P., MARINELLI L., FORNASARI E., CACCIATORE I., ...More

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.485, pp.183-191, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 485
  • Publication Date: 2015
  • Doi Number: 10.1016/j.ijpharm.2015.03.001
  • Title of Journal : INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Page Numbers: pp.183-191

Abstract

Solid lipid nanoparticles (SLNs) are considered very attractive drug-delivery systems (DDS) able to enhance the efficacy of some therapeutic agents in several pathologies difficult to treat in a conventional way. Starting from these evidences, this study describes the preparation, physicochemical characterization, release, and in vitro cytotoxicity of stealth SLNs as innovative approach to improve solubility and absorption through the gastrointestinal tract of lipoyl-memantine (LA-MEM), a potential anti-Alzheimer codrug.