Solid lipid nanoparticles loaded with lipoyl-memantine codrug: Preparation and characterization

LASERRA S., BASIT A., SOZIO P., MARINELLI L., FORNASARI E., CACCIATORE I., ...Daha Fazla

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.485, ss.183-191, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 485
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.ijpharm.2015.03.001
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-191
  • Anahtar Kelimeler: Alzheimer's disease, Codrug, Memantine, Lipoic acid, Solid lipid nanoparticles, LONG-TERM STABILITY, DRUG-DELIVERY, FORMULATION, MICROPARTICLES, OPTIMIZATION, SLN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Solid lipid nanoparticles (SLNs) are considered very attractive drug-delivery systems (DDS) able to enhance the efficacy of some therapeutic agents in several pathologies difficult to treat in a conventional way. Starting from these evidences, this study describes the preparation, physicochemical characterization, release, and in vitro cytotoxicity of stealth SLNs as innovative approach to improve solubility and absorption through the gastrointestinal tract of lipoyl-memantine (LA-MEM), a potential anti-Alzheimer codrug.