Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis


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Küçükler S. , Darendelioglu E., Caglayan C. , Ayna A., Yıldırım S., Kandemir F. M.

LIFE SCIENCES, vol.259, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 259
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118382
  • Title of Journal : LIFE SCIENCES

Abstract

Aim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methi-cillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats.