Comparison of reducing effect on lung injury of dexamethasone and bosentan in acute lung injury: an experimental study

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ARAZ Ö., DEMİRCİ E., Ucar E. Y., Calik M., Pulur D., KARAMAN A., ...Daha Fazla

MULTIDISCIPLINARY RESPIRATORY MEDICINE, cilt.8, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/2049-6958-8-74
  • Dergi Adı: MULTIDISCIPLINARY RESPIRATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Acute lung injury, Bosentan, Dexamethasone, SEVERE SEPSIS, ENDOTHELIN-1, INFLAMMATION, ARDS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Different medical therapies are employed in acute lung injury (ALI) but there is still a debate about the efficacy of these drugs. Among these therapies steroids are clinically applied and bosentan is experimentally studied. The aim of this study was to evaluate the efficacy of these two drugs to treat inflammation in ALI by histopathological comparison.