Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture

Köse D., Kose A., Halıcı Z., Gurbuz M. A., Aydın A., Uğan R. A., ...More

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.887, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 887
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ejphar.2020.173577
  • Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Melatonine, Agomelatine, Ramelteon, Fracture healing, MT2 RECEPTORS, OSTEOPOROSIS
  • Ataturk University Affiliated: Yes

Abstract

Melatonin improves fracture healing, but the long-term use of melatonin seems impracticable in the treatment of fracture due to side effects caused by hormonal stress on chronological rhythm. Ramelteon (RAMEL) and agomelatine (AGO) are non-selective peripheral melatonin receptor (MT) agonists. This study investigated the effects on bone fracture healing of these MT agonists, which do not affect the central nervous system.