Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture


KÖSE D. , Kose A., HALICI Z. , Gurbuz M. A. , AYDIN A. , UĞAN R. A. , ...More

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.887, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 887
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ejphar.2020.173577
  • Title of Journal : EUROPEAN JOURNAL OF PHARMACOLOGY
  • Keywords: Melatonine, Agomelatine, Ramelteon, Fracture healing, MT2 RECEPTORS, OSTEOPOROSIS

Abstract

Melatonin improves fracture healing, but the long-term use of melatonin seems impracticable in the treatment of fracture due to side effects caused by hormonal stress on chronological rhythm. Ramelteon (RAMEL) and agomelatine (AGO) are non-selective peripheral melatonin receptor (MT) agonists. This study investigated the effects on bone fracture healing of these MT agonists, which do not affect the central nervous system.