A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver

Özgençli I., KILIÇ D., Guller U., Ciftci M., Kufrevioglu Ö. İ., BUDAK H.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.14, ss.2053-2061, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 14
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180910093335
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2053-2061
  • Anahtar Kelimeler: Anticancer drug, inhibition, molecular docking, thioredoxin reductase, glutathione s-transferase, rat liver, MAMMALIAN THIOREDOXIN, GENE STRUCTURE, METAL-IONS, CANCER, PURIFICATION, ENZYMES, CONJUGATION, TOXICITY, IDENTIFICATION, MITOXANTRONE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: While Thioredoxin Reductase (TrxR) plays an important role in regulation of the intracellular redox balance and various signalling pathways, Glutathione S-Transferase (GSTs) enzymes belong to the detoxification family that catalyse the conjugation of glutathione with various endogenous and xenobiotic electrophiles. Since TrxR and GSTs are overexpressed in many cancer cells, they have been identified as potential targets to develop chemotherapeutic strategies.