A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver

Özgençli I., KILIÇ D., Guller U., Ciftci M., Kufrevioglu Ö. İ., BUDAK H.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.18, no.14, pp.2053-2061, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 14
  • Publication Date: 2018
  • Doi Number: 10.2174/1871520618666180910093335
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2053-2061
  • Keywords: Anticancer drug, inhibition, molecular docking, thioredoxin reductase, glutathione s-transferase, rat liver, MAMMALIAN THIOREDOXIN, GENE STRUCTURE, METAL-IONS, CANCER, PURIFICATION, ENZYMES, CONJUGATION, TOXICITY, IDENTIFICATION, MITOXANTRONE
  • Ataturk University Affiliated: Yes

Abstract

Background: While Thioredoxin Reductase (TrxR) plays an important role in regulation of the intracellular redox balance and various signalling pathways, Glutathione S-Transferase (GSTs) enzymes belong to the detoxification family that catalyse the conjugation of glutathione with various endogenous and xenobiotic electrophiles. Since TrxR and GSTs are overexpressed in many cancer cells, they have been identified as potential targets to develop chemotherapeutic strategies.