Drug loading with supercritical carbon dioxide deposition on different silica derivatives: Carvedilol study


ÖZÇELİK N., Yurtcan A.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.53, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jddst.2019.101213
  • Title of Journal : JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Abstract

Supercritical carbon dioxide is a promising method used to load water insouble drugs over different drug carriers. In this study, it is offered as an alternative method to load Carvedilol as a drug over different kinds of silica materials via supercritical carbon dioxide method. Two kinds of silica materials either spherical silica or MCM-41 were synthesized for this purpose. The characterization of the silica materials were carried out by using SEM, BET, XRD and FT-IR. Spherical silica materials were obtained by changing the synthesis temperatures as 70, 80 and 90 degrees C. The diameters of the synthesized silica structures were increased with an increase in the temperature. Among the other spherical silica materials, the best homogeneity was obtained for 70 degrees C synthesis temperature so it is chosen as drug carrier for spherical silica. BET surface areas of spherical silica and MCM-41 were 345.9 m(2)/g and 1057.0 m(2)/g, respectively. Carvedilol, poorly water souble drug, was loaded over spherical silica and MCM-41 and subsequently characterized by XRD, BET, SEM and FT-IR. Carvedilol was loaded over these silica materials. Drug loading over these materials were achieved as 42% and 26% for spherical silica and MCM-41, respectively.