Oral Ulcers as an Initial Presentation of Pemphigus. Two Case Report

Gündoğdu B., Doğan M., Erdem H., Bilen H., Gürsan N.

Oral Surgery Oral Medicine Oral Pathology Oral Radiology, vol.119, no.3, pp.207-208, 2015 (SCI-Expanded)


Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucosa. The classic presentations of PV are flaccid vesicles or bullae over the oral mucosa, trunk, groin, and extremities. Pemphigus vulgaris affects the oral mucosa in nearly all cases. We report here two case of pemphigus vulgaris of gingiva in an adult female patient at an early stage followed by dermatologic involvement. Perilesional incision was taken and histopathological and direct immunofluorescence was done for identification of specific antibodies. However, PV was confirmed by hematoxylin and eosin staining and immunofluorescence examination of the skin biopsy specimens. Keywords: Pemphigus vulgaris, oral mucosa, direct immunofluorescence