Artemisia herba-alba was investigated for its possible anti-diabetic effect in alloxan-induced diabetic rats. Oral administration of 0.39 g/kg b.w. of the aqueous Solution of Artemisia herba-alba exhibited a significant reduction in blood glucose content. The same effect was also seen after administration of repaglinide (1 mg/kg bw.) and regular insulin (0.1 IU/kg b.w.). It was demonstrated that the anti-diabetic effect of Artemisia herba-alba was similar to that of repaglinide and regular insulin. These results suggest that the Artemisia herba-alba possesses antidiabetic activity and is able to ameliorate biochemical damages in alloxan induced diabetes in rats.