Research Information System
Aquaculture, vol.621, 2026 (SCI-Expanded, Scopus)
The gut-brain axis (GBA) is a complex bidirectional communication system that connects the gastrointestinal tract to the central nervous system via hormonal, neuronal, and immunological signaling pathways. There is growing evidence that the gut microbiota regulates this interaction by generating neuroactive and metabolites substances that affect brain function and behavior. The microbiome–gut–brain axis has been thoroughly investigated in mammals, but little is known about this system in fish. With a focus on the makeup of the gut microbiome, interactions between the microbiome and neurotransmitters, and the function of microbial metabolites like short-chain fatty acids in neural regulation, this review provides a thorough summary of the state of knowledge regarding the gut brain axis in fish. The review additionally appears at how the gut microbiome affects stress responses and neuroendocrine control via processes connected to the hypothalamus pituitary interrenal axis. Additionally, recent methodological developments are emphasized as prospective tools for examining gut-brain interactions in aquatic organisms, such as multi-omics approaches and new sequencing technologies. This review aims to provide a thorough foundation for future investigations on fish microbiome gut brain connections and their possible applications in aquaculture and fish management of health by summarizing current results and highlighting important research gaps.