Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

Çetin M., Vural İ., Atila A., Kadıoglu Y.

Turkish Journal of Chemistry, cilt.34, ss.509-516, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/kim-0910-237
  • Dergi Adı: Turkish Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.509-516
  • Anahtar Kelimeler: Doxorubicin, PLGA, RG2 cell line, microparticles, BLOOD-BRAIN-BARRIER, POLY(BUTYL CYANOACRYLATE) NANOPARTICLES, CENTRAL-NERVOUS-SYSTEM, GUIDED FOCUSED ULTRASOUND, IN-VITRO, LOCAL-DELIVERY, CONTROLLED-RELEASE, ENHANCED DELIVERY, MALIGNANT GLIOMA, CYCLOSPORINE-A
  • Atatürk Üniversitesi Adresli: Evet

Özet

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 +/- 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.