Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives
Future Medicinal Chemistry, cilt.13, sa.15, ss.1285-1299, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 15
- Basım Tarihi: 2021
- Doi Numarası: 10.4155/fmc-2020-0387
- Dergi Adı: Future Medicinal Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1285-1299
- Anahtar Kelimeler: antibacterial, azido sulfonyl carbamate, carbonic anhydrase, drug likeness, structure-activity relationship, THERAPEUTIC APPLICATIONS, ANTIMICROBIAL ACTIVITY, DRUGS, ANTICANCER, DISCOVERY, IX
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
The aim of this study was to identify inhibition of carbonic anhydrase I and II (CA I and II) isozymes
by azido sulfonyl carbamates through both in vitro and in silico approaches and also to determine the
drug-likeness properties and antibacterial activities of azido sulfonyl carbamates. Methods & Results: In
vitro inhibition and molecular docking studies of azido sulfonyl carbamate derivatives (1–4) on isozymes
were performed. Except for derivative 4, all derivatives inhibited human CA I and II. Almost all compounds
had antibacterial effects. The docking results showed that compound 3 had the best results, with binding
energy of -8.20 kcal/mol for human CA I and -8.24 kcal/mol for human CA II. Conclusion: Molecule 4
inhibited only CA I. Its usage as a potential chemotherapeutic agent specific to the CA I isozyme may be
considered.