Akademik Veri Yönetim Sistemi
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.32, sa.2, ss.432-437, 2012 (SCI-Expanded)
Objective: In this study we described the predictors of fatality among Crimean-Congo hemorrhagic fever (CCHF) patients who admitted to our hospital based on epidemiological, clinical and laboratory findings between 2005 and 2006. Material and Methods: Definitive diagnosis was based on the detection of CCHF virus-specific IgM by ELISA and/or of genomic segments of the CCHF virus by real time polymerase chain reaction. Related data were collected prospectively. Results: The study included 63 patients. Thirty-two of the patients (50.8%) were females and 31 of them (49.2%) were males. The overall case fatality rate was 4.8%. The age and sex were similar between favorable and fatal cases (p>0.05). The mean duration to the onset of symptoms for all patients was 4.7 days and differences in the mean duration to the onset of symptoms between surviving and died patients were not statistically significant (p=0.22). Weakness, myalgia, somnolence, bleeding from multiple sites and presence of petechia/ecchymosis were observed more often in the patients who died (p=0.02, p=0.03, p=0.015, p=0.02, respectively). Significant elevation of LDH levels (p=0.004), prolonged APT (p=0.004), prolonged PT (p=0.04) and thrombocytopenia (p=0.01) were detected in patients who died. Oral ribavirin was prescribed to 46 patients (73%). Prescription of ribavirin was considered to three patients with fatal disease, but this could not be realized because of hematemesis and melena. Conclusion: The existence of various clinical and laboratory findings like weakness, myalgia, somnolence, bleeding, elevation of LDH levels, prolonged APT and PT and thrombocytopenia may be considered as risk factors for fatality in CCHF.