Preparation of three-dimensional graphene free-standing electrochemical sensor and its potential application in glucose determination


Zhai X., Chen P., Cao W., Liu J., Abd El-Aty A. M., Hacımüftüoğlu A., ...More

Journal of the Iranian Chemical Society, vol.17, no.11, pp.2845-2853, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.1007/s13738-020-01961-8
  • Journal Name: Journal of the Iranian Chemical Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.2845-2853
  • Keywords: Three-dimensional graphene, Free-standing electrode, Electrochemical sensor, Glucose, OXIDE, NETWORKS
  • Ataturk University Affiliated: Yes

Abstract

© 2020, Iranian Chemical Society.Abstract: Lightweight, flexible electrodes based on three-dimensional (3D) graphene have attracted increasing attention owing to their potential applications in many fields. In this work, we developed 3D graphene through different methods and evaluated the potential of these materials as free-standing electrodes. Finally, the 3D graphene synthesized by hydrothermal gelation with cobalt ions as a cross-linking agent had the best electrochemical sensor performance. With our focus on practical applications, we further modified polydopamine and concanavalin A onto the 3D graphene to make it suitable for the detection of glucose. Under the optimum conditions, the impedance change in the free-standing electrode and the concentration of glucose have a good linear relationship in the range of 0.05–0.35 μmol/L and a limit of detection of 0.01 μmol/L. The electrochemical biosensor exhibited good sensitivity, selectivity, reproducibility, and stability. The fabricated biosensor was employed for the detection of glucose in mouse serum samples and provided satisfactory results. Therefore, the synthesized 3D graphene offers a new opportunity for immobilizing other biomolecules and fabricating biosensors. Graphic abstract: Preparation of functionalized three-dimensional graphene free-standing electrochemical sensor.[Figure not available: see fulltext.]