JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, vol.4, pp.344-350, 2013 (ESCI)
Epilepsy is a short-term neurological disease that results from unusual, sudden, excessive and abnormal electrochemical discharge. Epilepsy is accompanied by depression and this situation is a serious problem for people who has wrong diagnosis in terms of decreased life quality. Epileptic patients with depression are more vulnerable to side effects of antiepileptic drugs and they are more resistant to drug when compared to nondepressed epileptic patients. When used in combination with psychoactive drugs, these drugs have become increasingly common for the treatment of mood disorders in epilepsy. Pharmacokinetic interactions may occur at various stages of drug absorption, distribution, biotransformation and excretion. The question of whether there is an increased risk of depression in epileptic patients or there is an increased risk of epilepsy in patients with depression has not answered yet in the light of current knowledge. So depression treatment in epileptic patients is an important issue to be dwelled upon. When treating depression in epileptic patients, drug should be chosen carefully. Dosing should be started in small doses and optimal dose should be determined. Finally because of antidepressants and antiepileptic drugs are similar in terms of places they affect and places in which they undergo metabolization, one should be very careful in their pharmacokinetic and pharmacodynamic interactions.