Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis

Atila, Nihal; Kaya, Zulkuf; Atila, Alptuğ; Halici, Zekai; Bayir, Yasin; Sirin, Busra; Kahramanlar, Aysenur; Cadirci, Elif; Ozkaraca, Mustafa; Keles, Osman; Ozmen, Sevilay

doi:10.5152/b-ent.2022.21476

Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis

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Atila N. E., , Kaya Z., Atila A., Halici Z., Bayir Y., ...More

B-ENT, vol.18, no.4, pp.216-224, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 18 Issue: 4
Publication Date: 2022
Doi Number: 10.5152/b-ent.2022.21476
Journal Name: B-ENT
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
Page Numbers: pp.216-224
Keywords: Alpha-lipoic acid, antibiotics, antioxidant, bacterial rhinosinusitis, MECHANISMS, PROTECTS, DAMAGE, ASSAY, MODEL
Ataturk University Affiliated: Yes

Abstract

Objective: Alpha-lipoic acid is an antioxidant agent with potential anti-inflammatory properties and is produced from octanoic acid. The aim of this study was to investigate the effects of alpha-lipoic acid on inflammation, oxidative status, tissue integrity in an animal model of experimentally induced acute rhinosinusitis and to compare these effects with the standard treatment, cefalosporin.