Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB(1) in human lymphocytes in vitro

KOTAN E., Alpsoy L., Anar M., Aslan A., AĞAR G.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.27, sa.7, ss.599-605, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/0748233710394234
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.599-605
  • Anahtar Kelimeler: Cetraria islandica, antigenotoxicity, antioxidant enzymes, ANTIOXIDANT ACTIVITY, AFLATOXIN B-1, DAMAGE, LICHENS, METABOLITES, ARTVIN, TURKEY, ASSAY, ACID, RATS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the antigenotoxic and antioxidant effects of Cetraria islandica methanol (CME) extract were determined by using sister chromatid exchange (SCE), micronuclei (MN) assays and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against effects of aflatoxin B1 (AFB(1)) induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN and MDA level decreased, SOD and GPx activities increased when 5 mg/mL and 10 mu g/mL doses of CME were added to AFBi-treated cultures. Also, the present results indicate that CME has strong antioxidative and the antigenotoxicity mechanisms of CME are associated with its antioxidant nature.