Modulatory effects of carvacrol against cadmium-induced hepatotoxicity and nephrotoxicity by molecular targeting regulation

KANDEMİR F. M., ÇAĞLAYAN C., DARENDELİOĞLU E., KÜÇÜKLER S., Izol E., Kandemir O.

LIFE SCIENCES, cilt.277, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 277
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.lfs.2021.119610
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Apoptosis, Cadmium, Carvacrol, Hepatotoxicity, Nephrotoxicity, Oxidative stress, OXIDATIVE STRESS, PROTECTIVE ROLE, APOPTOSIS, INFLAMMATION, LIVER, RATS, PROANTHOCYANIDINS, SUPPRESSION, MECHANISM, TISSUE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Cadmium (Cd) is a toxic heavy metal that causes severe toxic effects on different tissues including liver and kidney. Therefore the research for alternatives to reduce the damage caused by Cd has substantial importance. This study was performed to examine the possible modulatory effects of carvacrol (CRV) against Cd-induced hepatorenal toxicities and the possible mechanisms underlying these effects.