Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro

Polat B., HALICI Z., ÇADIRCI E., Karakus E., BAYIR Y., ALBAYRAK A., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.43, pp.227-235, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43
  • Publication Date: 2017
  • Doi Number: 10.1016/j.intimp.2016.12.023
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.227-235
  • Keywords: Serotonin, Liver injury, Fibrosis, Inflammation, CCI4, CARBON-TETRACHLORIDE, RISK-FACTORS, SEROTONIN, GROWTH, CELLS, INHIBITION, ANTAGONIST, MECHANISMS, SB-269970, STRESS
  • Ataturk University Affiliated: Yes

Abstract

Background and aim: Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of the serotonin receptor family and is expressed in both central nerve system and peripheral system and have a lot of functions like learning, memory, smooth muscular relaxation, in the control of circadian rhythms and thermoregulation, pain and migraine, schizophrenia, anxiety, cognitive disturbances, and even inflammation.