Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

Cinar I., Sirin B., Aydin P., TOKTAY E. , ÇADIRCI E. , Halici I., ...More

LIFE SCIENCES, vol.221, pp.327-334, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 221
  • Publication Date: 2019
  • Doi Number: 10.1016/j.lfs.2019.02.039
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.327-334


Aims: Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs.