Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

Cinar I., Sirin B., Aydin P., TOKTAY E., ÇADIRCI E., Halici I., ...Daha Fazla

LIFE SCIENCES, cilt.221, ss.327-334, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 221
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.lfs.2019.02.039
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-334
  • Anahtar Kelimeler: CLP, Lung injury, Gossypin, NLRP3, HMG beta 1, NF-kappa B, ISCHEMIA-REPERFUSION INJURY, ALPHA-LIPOIC ACID, CECAL LIGATION, KAPPA-B, SEPTIC SHOCK, LIPID-PEROXIDATION, GENE-EXPRESSION, RECEPTOR 4, HMGB1, PROTEIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aims: Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs.