Roles of Ki-67, p53, transforming growth factor-beta and lysyl oxidase in the metastasis of lung cancer

ARAZ Ö., DEMİRCİ E., YILMAZEL UÇAR E., Calik M., KARAMAN A., DURUR SUBAŞI I., ...Daha Fazla

RESPIROLOGY, cilt.19, sa.7, ss.1034-1039, 2014 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/resp.12345
  • Dergi Adı: RESPIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1034-1039
  • Anahtar Kelimeler: Ki-67, lung cancer, lysyl oxidase, p53, TGF-beta, POSITRON-EMISSION-TOMOGRAPHY, TGF-BETA, PROGNOSTIC-SIGNIFICANCE, POOR-PROGNOSIS, SURVIVAL, ADENOCARCINOMA, EXPRESSION, STAGE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background and objectiveMost lung cancer (LC) patients have metastatic disease at time of diagnosis, which influence the treatment regimen and is the most important prognostic factor. The main purpose of our study was to evaluate the relationship between cell proliferation (Ki-67 label index), p53, transforming growth factor- (TGF-) and lysyl oxidase (LOX), and the metastatic stages of different lung cancers. The secondary aim was to correlate these parameters with the standardized uptake value (SUVmax) of the primary lesion during positron emission tomography-computed tomography (PET-CT).