A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

Kalkan S., Efe S. C., Karagoz A., Zeren G., Yilmaz M. F., Simsek B., ...Daha Fazla

ANGIOLOGY, cilt.73, sa.5, ss.461-469, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1177/00033197211066362
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.461-469
  • Anahtar Kelimeler: uric acid, albumin ratio, ST-elevation myocardial infarction, mortality, uric acid, albumin, CORONARY-HEART-DISEASE, ALL-CAUSE MORTALITY, SERUM-ALBUMIN, CARDIOVASCULAR-DISEASE, INDEPENDENT PREDICTOR, RISK-FACTOR, ADMISSION, LEVEL, HYPERURICEMIA, MECHANISMS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Several studies have shown that high uric acid (UA) and low serum albumin (SA) values increase the risk of cardiovascular disease and mortality in ST-elevation myocardial infarction (STEMI). We determined whether the uric acid/albumin ratio (UAR) is a predictor of mortality in STEMI patients. All patients who presented at our center with a diagnosis of STEMI and underwent percutaneous intervention from 2015 to 2020 were screened consecutively; 4599 patients were included. A Cox proportional hazards model was used to evaluate UAR, and adjusted predictors obtained from laboratory findings and clinical characteristics contributed to mortality. Also, a regression model was presented with a directed acyclic graph (DAG). The median age of the patients was 58 years (IQR [interquartile range]: 50-67); 3581 patients (77.9%) were male. The incidence of mortality in the entire patient group was 11.9%. Median follow-up duration of all groups was 42 months. Multivariate Cox proportional regression (model-1) analysis showed age (increase 50 to 67 years; HR [hazard ratio]: 1.34, 95% CI 1.18-1.52) and UAR (increase 1.15-1.73; HR: 1.33, 95% CI 1.16-1.52) were associated with mortality. UAR may be a prognostic factor for mortality in STEMI patients and an easily accessible parameter to identify high-risk patients.